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Han Nanyin

  

Han Nanyin

School of Pharmaceutical Sciences, Peking University, Associate Professor

Research Areas

Chemical  Biology

Pharmaceutical  Analysis

 

Education & Positions

Jiangxi Normal University, B.S., 1985.

China Pharmaceutical University, M.S., 1992.

Beijing Institute of Technology, Ph.D., 1999.

Guangfeng Senior High School, Jiangxi Province, Teacher 1985-1989.

China Pharmaceutical University, Research Assistant 1989-1992.

The Seventh Pharmaceutical Manufacturing Company, wuxi, Jiangsu Province, China, Chemical Engineer 1992-1996.

Beijing Institute of Technology, Assistant Professor 1996-1999.

School of Pharmaceutical Sciences, Peking University, Associate Professor 1999-2004.

Department of Chemistry, Helsinki University, Finland, Advanced Exchange Scholar, 2004-2005.

School of Pharmaceutical Sciences, Peking University, Associate Professor, Director, 2004-2012.

School of Pharmaceutical Sciences, Peking University, Associate Professor 2012-.

 

Faculty Accolades

Peking University Health Science Center Prominent Teacher Award 2014.

Peking University Health Science Center Excellent Teaching Award 2017.

 

Research Interests

Our research focuses on the development of Field Flow Fractionation (FFF) instruments which based on separation and purification of macromolecules. There are two major problems that perplex people to control the mass of macromolecules: (1) Biological macromolecules in the process of separation and purification are easy to lose their activity; (2) Relative molecular weight distribution and molecular size measurement are too inaccurate or difficult to determine. We have successfully developed two sets of FFF instruments. One is Asymmetrical Flow Field Flow Fractionation (AF4). we applied it without packing materials for the separation and characterization of allergenic proteins and immunoglobulins for the first time. AF4 for allergy protein and IgE separation methods is established; flow velocity, carrier fluid and sample injection amount are optimized to ensure total separation of allergenic protein and immunoglobulins,FFF theory was used to verify and explain the rationality and feasibility of the experiment. The other is Gravitational Field Flow Fractionation (GrFFF). The device of GrFFF has been assembled to separate and characterize the particle size of five medicinal starch such as corn, pea, wheat, potato and waxy corn etc.

 

Grants and fundings

Science and Technology Support Plan (2009 BAI75B03), Ministry of Science and Technology (RMB 500,000)

Principal Investigator

 

Publications

1. Shuang Guo, Chen-Qi Zhu, Ya-Ya Gao Yang, Bai-Ling Qiu, Di Wu, Qi-Hui Liang, Nan-Yin Han*. Effects of Comprehensive Function of Factors on Retention Behavior of Microparticles in Gravitational Field-Flow Fractionation. Journal of Chromatography B. 2016, 1031: 1-7.

2. Yaya Gaoyang1, Chenqi Zhu1, Shuang Guo1, Bailing Qiu1, Di Wu1, Ye Gao1, Qihui Liang1, Ping zhang2, Nanyin Han1*. Determination of Gallic Acid in the Traditional Chinese Medicine by High-Performance Capillary Electrophoresis. Journal of Chinese Pharmaceutical sciences. 2016, 25(10): 747-753.

3. Ye Gao, Bailing Qiu, Qihui Liang, Di Wu, Yu Song, Nanyin Han*.Application of avidin-phospholipid vesicle complex as the stationary phase for chiral separation in open-tubular capillary electrochromatography. Journal of Chinese Pharmaceutical Sciences. 2017, 26 (12): 872–880.