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Ling Xiaomei

Ling Xiao-mei, Professor  

Tel: +86-10-82801590(O); +86-10-82805154(L)
Fax: +86-10-82802414
Email: lingxm@bjmu.edu.cn; pkulxm@126.com
Address: Division of Pharmaceutical Analysis
              Department of Chemical Biology
              School of Pharmaceutical Sciences
              Peking University
              Xueyuan Road 38, Beijing 100191, China



Professional Details

LING Xiao-mei is a professor of pharmaceutical analysis, the associate director of Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, the editorial board member of Chinese Journal of Pharmaceutical Analysis and the Pharmaceutical Analysis Committee member of Chinese Pharmaceutical Association. She has been engaging in the teaching and research of instrumental analysis and pharmaceutical analysis since 1982, published a text book (Experiment and Technique of Advanced Instrumental Analysis) for postgraduate students, and obtained some valuable results in the following research works: (1) researches on drug pharmacokinetics and metabonomics: adopting chromatographic hyphenated technology to study the ADMET of new drugs in biosome; (2) investigating interactions between biomolecules and interactions of biomolecules with drug molecules; (3) qualitative and quantative screening of drugs; (4) separation of chiral drugs and their interactions with biomacromolecules; (5) coating capillary columns by immobilization protein or receptor-over-expressed cells and their applications in drug domain; (6) DNA separation and steady-state kinetics study of nucleotide analogues incorporation using non-gel capillary electrophoresis; (7) researches on quality standards and stability of new medicines; and (8) determinating the content of in vivo and in vitro fatty acids.


Research Interests

    1. Developing and discovering new suitable methods and technologies for biomedical and pharmaceutical analysis
     2. Pharmacokinetic and metabolomic researches
     3. Researches on quality standards and stability of new medicines

Teaching

     1. Quantitative Analysis
     2. Instrumental Analysis
     3. Pharmaceutical Analysis
     4. Advanced Instrumental Analysis
     5. Capillary Electrophoresis
     6. Biopharmaceutical Analysis
     7. Quantitative Analytical Experiment
     8. Instrumental Analytical Experiment
     9. Pharmaceutical Analytical Experiment
     10. Advanced Instrumental Analytical Experiment


Recent Publications

1.  Wen-Jing Chen, Pazilaiti.Yakufu, Xiao-Mei Ling, Hui Qi, Jun-Hai Xiao, Ying Wang, N-terminal extracellular tail of CC chemokine receptor 4 (ML40) immobilized on capillary column to study the interactions between ML40 and its potential ligands, Analytical BiochemistryRevised

2.  Shuyu Zhang, Hui Qi, Pazilaiti. Yakufu, Fang Zhao, Xiaomei Ling, Junhai Xiao, Ying Wang, Screening of thiourea derivatives and carbonyl-2-aminothiazole derivatives for potential CCR4 antagonists using capillary zone electrophoresis, Journal of Chromatography B, 2011, 879: 75-82

3.  Wujie Li, Yinling Ma, Zhu Gan, Xiaomei Ling, Zhenjun Yang, Qualitative and quantitative determination of oligonucleotide by non-gel capillary electrophoresis, Chromatographia, 2011, 73: 579-582

4.  Lu Pei, Lujia Xie, Qian Lin, Xiaomei Ling, Zhu Guan, Zhenjun Yang, Studies on the adenosine deaminase-catalyzed conversion of adenosine and nucleoside prodrugs by different capillary electrophoresis modes, Analytical Biochemistry, 2011, 414: 131-137

5.  Xiaomei Jing, Yihao Bai, Xiaomei Ling, Fangbin Han, Runtao Li, Jingrong Cui, Simultaneous determination of 4-methyl-piperazine-1-carbodithioc acid 3-cyano-3,3-diphenylpropyl ester hydrochloride and its major metabolite in rats by high-performance liquid chromatography, Journal of Chromatography Science, 2010, 48: 125-129

6.  Wujie Li, Mou Cao, Lu Pei, Xiaomei Ling, Bingchao Li, Zhenjun Yang, Study on steady-state kinetics of nucleotide analogues incorporation by non-gel capillary electrophoresis, Electrophoresis, 2010, 31: 507-511

7.  Wenjing Chen, Wujie Li, Xiaomei Ling, Xiaowei Wang, Junyi Liu, Study on the interaction between HIV reverse transcriptase and its non-nucleoside inhibitor nevirapine by capillary electrophoresis, Journal of Chromatography B, 2010, 878: 1714-1717

8.  Siting Wang, Yan Song, Jiao Wang, Xiaomei Ling, Zemei Ge, Runtao Li and Jingrong Cui, Gas-fragmentation study of the novel synthetic zwitterionic drug 3-methyl-9-(2-oxa-2λ5-2H-1,3,2-oxazaphosphorine-2-cyclohexyl)-3,6,9- triazaspiro[5,5]undecane chloride (SLXM-2) by electrospray ionization tandem mass spectrometry, Rapid Communications in Mass Spectrometry, 2010, 24: 1181-1184

9. Jiao Wang, Yan Song, Jianmei Zhang, Xiaona Li, Xiaomei Ling, Runtao Li and Jingrong Cui, LC and LC–MS Study of the Bioavailability and Metabolites of TM208 after Oral and Intravenous Administration to Rat, Chromatographia, 2010, 72: 459-464

10.Shuyu Zhang, Jun Cheng, Wenjing Chen, Xiaomei Ling, Yiying Zhao, Jie Feng , Cheng Xiang , Hong Liang, Interactions between thrombin and natural products of Millettia nitita var. hirsutissima using capillary zone electrophoresis, Journal of Chromatography B, 2009, 877: 4107-4114

11.Detao Kong, Siting Wang, Xiaomei Ling, Runtao Li, Jingrong Cui, Determination of anti-tumor agent TM208, 4-methyl-piperazine-1-carbodithioc acid 3-cyano-3,3-diphenylpropyl ester hydrochloride, in rats by LC, Chromatographia, 2009, 70: 1721-1725

12.Wenjing Chen , Ke Mou, Bo Xu, Xiaomei Ling, Jingrong Cui, Ping Xu, Capillary electrophoresis for screening of 20S proteasome inhibitors, Analytical Biochemistry, 2009, 394(11): 62-67

13.Zhe Sun, Xiaomei Ling, Yingmei Zhang, Linjie Tian, Ying Wang, Interactions of the peptides from secreted human CKLF1 and the N-terminal extracellular tail of CCR4 analyzed by capillary zone electrophoresis, Chromatographia, 2009, 70(1/2): 287-292

14.Wenjing Chen, Xiaomei Ling, Advances of methods of protein immobilization on capillary, Chinese Journal of Analytical Chemistry, 2009, 37(6): 929-934.

15.Yihao Bai, Zhen Chen, Xiaomei Ling, Runtao Li, Jingrong Cui, Determination of chloride 3-methyl-9-(2-oxa-2k5-2H-1,3,2- oxazaphosphorine-cyclohexyl)-3,6,9- triazaspiro [5.5] undecane (SLXM-2) in rats by LC:application to a pharmacokinetic study, Chromatographia, 2009, 69(1-2): 111-115

16.Shuyu Zhang, Ting Yin, Xiaomei Ling, Hong Liang, Yuying Zhao, Interactions between thrombin and natural products of Millettia speciosa Champ. using capillary zone, Electrophoresis, 2008, 29(16): 3391-3397

17.Yi Liu, Shuyu Zhang, Xiaomei Ling, Yuzhen Li, Yingmei Zhang, Wenling Han, Ying Wang, Analysis of the interactions between the peptides from secreted human CKLF1 and heparin using capillary zone electrophoresis, Journal of Peptide Science, 2008, 14(8): 984-988

18.Yi Liu, Wujie Li, Xiaomei Ling, Xianyin Lai, Yuzhen Li, Qingying Zhang, Yuying Zhao, Simultaneous determination of the active ingredients in Abelmoschus manihot (L.) Medicus by CZE, Chromatographia, 2008, 67(9-10): 819-823

19.Detao Kong, Xiaomei Ling, Fangbin Han, Zemei Ge, and Jingrong Cui, Identification of the metabolite and cytochrome P450 isoforms involved in rat liver microsomal metabolism of TM208, Journal of Chinese Pharmaceutical Sciences, 2008, 17(1): 30-34

20.Zhe Sun, Xiaomei Ling, Wei Sun, Junhai Xiao, Caihua Yin, Ying Wang, Studies on the interactions between lactam analogs and the N-terminal extracellular tail of CC chemokine receptor 4 by CZE (p NA), Electrophoresis, 2007, 28(17): 3064-3069

21.Liu Yi, Xiaomei Ling, Fan Hui, Zhong Yingcheng, Li Dan, Wang Ying. Determination of binding constant and binding region of programmed cell death 5-heparin by capillary zone electrophoresis, Journal of Chromatography A, 2007, 1143(1-2): 284-287

22.Xiaomei Jiang, Xiaomei Ling, Fangbin Han, Runtao Li, Jingrong Cui, Analysis of 4-methyl-piperazine-1-carbodithioic acid 3-cyano-3,3- diphenyl-propyl ester hydrochloride and its major metabolites in rat plasma and tissues by LC-MS/MS, Journal of Separation Science, 2007, 30(13): 2080-2085

23.Xiaomei Jiang, Xiaomei Ling, Fangbin Han, Detao Kong, Xiaoyan Liu, Runtao Li, Jingrong Cui, Studies on the metabolism of 4-methyl-piperazine-1- carbodithioc acid 3-cyano-3,3-diphenylpropyl ester hydrochloride in rat bile by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry, Rapid Communications in Mass Spectrometry. 2007, 21(10): 1599-1605

24.Xiaomei Jiang, Xiaomei Ling, Fangbin Han, Runtao Li, Jingrong Cui, Studies on the metabolism of 4-methyl-piperazine- 1-carbodithioc acid 3-cyano-3,3-diphenylpropyl ester hydrochloride in rats by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis, 2007, 44(5): 1127-1132

25.Xiaomei Ling, Yi Liu, Hui Fan, Yingcheng Zhong, Dan Li, Ying Wang, Studies on interactions of programmed cell death 5 (PDCD5) and its related peptides with heparin by capillary zone electrophoresis, Analytical and Bioanalytical Chemistry, 2007, 387(3): 909-916

26.Liu Yi, Shi Haiming, Sun Zhe, Xiaomei Ling, Tu Pengfei, Enantiomer separation of the four diastereomers of guaiacyl glycerol from Hydnocarpus annamensis by capillary electrophoresis with HP-β-CD as chiral selector, Journal of Chromatography Science, 2007, 45(9): 605-609

27.Yi Liu, Haiming Shi, Zhe Sun, Xiaomei Ling, Pengfei Tu, Enantiomer separation of the four stereoisomers of 1-(4-hydroxy-3- methoxy)-phenyl-2- [4-(1,2,3-trihydroxy-propyl)-2-methoxy]-phenoxy-1,3-propandiol from Hydnocarpus annamensis by capillary zone electrophoresis with HP-β-CD as chiral selector, Chromatographia, 2006, 64(7-8): 483-486

28.Yi Liu, Xianyin Lai, Xiaomei Ling, Yuying Zhao, Jingrong Cui, Interactions Between Thrombin with Flavonoids from Abelmoschus manihot (L.) Medicus by CZE, Chromatographia, 2006, 64(1-2): 45-50.

29.Liu Yi, Zhang Yuan , Liu Xiaoming, Xiaomei Ling, Tu Pengfei, Cui Jingrong, Interactions between thrombin and natural proudcts of Coreopsis tinctoria Nuttt. & Cistanche deserticola Ma. in capillary zone electrophoresis, Journal of Chinese Pharmaceutical Sciences, 2006, 15(1): 38-44.