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李润涛

教授、博士生导师

 

李润涛教授, 博士生导师  化学生物学,药物化学

电话:010-82801504,

传真:010-82716956

电子信箱:Lirt@bjmu.edu.cn

联系邮箱: lirt@bjmu.edu.cn

简历

1981年获郑州大学化学专业学士学位;

1988年获郑州大学有机化学专业硕士学位;

1993年获大连理工大学精细化工专业博士学位;

1993-1995年在北京医科大学药学院从事博士后研究工作;

1996-2000年为北京医科大学药学院副教授;

2000-至今为北京大学药学院教授、博士生导师;

1997.11-1998.3德国波恩大学药物研究所DAAD高级访问学者;

2002.1-2002.9 美国Medinox药物研究公司访问教授。 

曾主持和正在主持的国家级科研项目10多项,已发表论文140余篇,申请专利10多项。为第一完成人获北京市科技进步二等奖1项。 

研究方向及兴趣

1   杂环化合物的合成及生物学功能研究

2   有机合成新方法、新试剂的研究

教学

高等有机合成(研究生)

杂环化学(选修课)

代表性文章:

1.     Junfeng Wang, Xin Wang, Zemei Ge,* Tieming Cheng, Runtao Li.* Highly enantioselective Michael addition of cyclopentanone with chalcones via novel di-iminium mechanism. Chem. Commun., 2010, 46, 1751-1753.

2.     Junfeng Wang, Chao Qi, Zemei Ge,* Tieming Cheng, Runtao Li.* Efficient direct asymmetric vinylogous Michael addition reactions of g-butenolides to chalcones catalyzed by vicinal primary-diamine salts. Chem. Commun., 2010, 46, 2124-2126.

3.     Junfeng Wang, Qin Li, Chao Qi, Yi Liu, Zemei Ge,* and Runtao Li*Primary 1,2-diamine catalysis III: An unexpected domino reaction for the synthesis of multisubstituted cyclohexa-1,3-dienaminesOrg. Biomol. Chem. 2010, 8, 4240 – 4242

4.     Xin Ai, Xin Wang*, Jin-ming Liu, Ze-mei Ge, Tie-ming Cheng, Run-tao Li* An effective Aza-Michael addition of aromatic amines to electron-de?cient alkenes in alkaline Al2O3. Tetrahedron, 2010, 66, 5373-5377.

5.     Shuai Xia, Xin Wang,* Ze-mei Ge, Tie-ming Cheng, Run-tao Li*. An ef?cient synthesis of aryldithiocarbamic acid esters from Michael addition of electron-de?cient alkenes with arylamines and CS2 in solid media alkaline Al2O3, Tetrahedron, 2009, 65, 1005-1009.

6.    Song-Wen Lin, Qi Sun, Ze-Mei Ge, Xin Wang, Jia Ye, Run-Tao Li. Synthesis and structure–analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ), Bioorg. Med. Chem. Lett. 2011, 21, 940-943.

7.     Yongqiang Zhu, Shuyang Yao, Bo Xu, Zemei Ge, Jingrong Cui, Tieming Cheng, Runtao Li*, Design, synthesis and biological evaluation of tripeptide boronic acid proteasome inhibitors, Bioorg. Med. Chem. 2009, 17, 6851–6861.

8.     Qi Sun, Cai-Qin Yue,a Jia Ye, Chang-Ling Li, Tie-Ming Cheng, Run-Tao Li*. Unique spirocyclopiperazinium salt III: Further investigation of monospirocyclo- piperazinium (MSPZ) salts as potential analgesics. Bioorg. Med. Chem. Lett., 2007, 17, 6245-6249.

9.     Ang Li, Xin Wang, Cai-Qin Yue, Jia Ye, Chang-Ling Li, Run-Tao Li*. Unique spirocyclopiperazinium salt. Part 4: Modification of dispirocyclo- piperazinium (DSPZ) salts as analgesicsBioorg. Med. Chem. Lett., 2007, 17, 5078-5081.

10.  Xueling Hou, Zemei Ge, Tingmin Wang, Wei Guo, Jingrong Cui, Tieming Cheng, Chingshan Lai, Runtao Li*. Dithiocarbamic acid esters as anticancer agent. Part 1: 4-Substituted-piperazine-1-carbodithioic acid 3-cyano-3,3-diphenyl-propyl esters, Bioorg. Med. Chem. Lett., 2006, 16, 4214-4219.

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代表性专利

1.李润涛,孙崎,叶加,岳彩琴,王欣,葛泽梅,李长龄,程铁明, 螺环哌嗪季铵盐类化合物及其制备方法和应用,WO(PTC/CN2007/00187),申请日期 2007, 6,15.

2.李润涛,孙崎,岳彩琴,叶加,王欣,葛泽梅,李长龄,程铁明,螺环哌嗪季铵盐类化合物及其制备方法和应用,中国专利,申请号:200610086917.3, 申请日:2006.6.16;

3.李润涛,程铁明,李长龄,高峰丽,王欣,张红梅, 具有镇痛作用的新型单哌嗪季铵盐类化合物, 中国专利,申请号:01142111.8, 申请日:2001.9.12; 专利号: ZL 01 1 42111.8, 授权公告日:2006.10.25;

4.李润涛,程铁明,崔景荣, 哌嗪基二硫代甲酸酯类化合物,它们的制备方法和在抗肿瘤药物中的应用, 中国专利,申请号:01118399.3, (2001.5.29); 专利号: ZL 01 1 18399.3(C07D295/14), 授权公告日:2004.7.14;

5.Run-tao Li,Tie-ming Cheng,Jing-rong Cui,Piperazine Mono(dithio)carbamate Ester Compounds and Analog: Preparation Method and Pharmaceutical Use, USP Apply No. 10/157733; WO Apply No. Pct/US 02/16772;

6.李润涛, 孙崎, 葛泽梅, 崔景荣, 程铁明, 环磷酰胺季铵盐衍生物及合成和应用, 中国发明专利, 申请号:200310100346.0;申请日:2003.10.13; 公开日:2005.4.20;

7.李润涛, 卫军, 王一强, 葛泽梅, 崔景荣, 程铁明, 芳甲氨基二硫代甲酸酯类化合物及其制备方法和应用, 中国专利,申请号:200410054686.9; 申请日:2004.7.27;公开日: 2006.2.1;

8.李润涛,程铁明,李长龄,高峰丽,王欣,张红梅, 具有镇痛作用的新型双哌嗪季铵盐类化合物,中国专利, 申请号:200510055643.7, 申请日:2005.3.18;