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张天蓝

教授、博士生导师

 

  

张天蓝  博士,教授,博士生导师

电话(010)-8280 1539 (办公室)

E-mail:   tlzhang@bjmu.edu.cn

通讯地址:北京市海淀区学院路38号,北京大学医学部药学院化学生物学系

邮编:100191

 

       197810月至19827月就读于华南工学院化学系,获化学专业理学学士学位。19849月至19877月就读于郑州大学/河南化学研究所,获无机化学专业理学硕士学位,此后在河南化学研究所从事配合物光化学和激发态电化学研究。19949月至19959月在英国帝国理工学院光分子科学中心(Centre for Photomolecular Sciences, Imperial College, London)学习光生物化学。1995年任河南化学研究所副研究员。19969月至19997月就读于北京医科大学,获药物化学专业理学博士学位并留校任教。2000年转为副教授,2004年至今为教授;其间,20056月至20081月曾任首都医科大学教授。

 

教学:

    讲授本科生课程无机化学和研究生课程固态生物无机化学。

 

科研:

    主要研究方向是抗白血病药物和生物矿化。

 

代表性论文:

1.   Zhang, Q.; Jiang, Y.; Gou, B.-D.; Huang, J.; Gao, Y.-X.; Zhao, J.-T.; Zheng, L.; Zhao, Y.-D.; Zhang, T.-L.; Wang, K., In situ detection of calcium phosphate clusters in solution and wet amorphous phase by synchrotron X-ray absorption near-edge spectroscopy at calcium K-edge. Cryst. Growth Des. 2015,15 (5), 2204-2210.

2.   Zhang, Z.-L.; Chen, X.-R.; Bian, S.; Huang, J.; Zhang, T.-L.; Wang, K., Identification of dicalcium phosphate dihydrate deposited during osteoblast mineralization in vitro. J. Inorg. Biochem. 2014,131 (0), 109-114.

3.   Du, L.; Bian, S.; Gou, B.-D.; Jiang, Y.; Huang, J.; Gao, Y.-X.; Zhao, Y.-D.; Wen, W.; Zhang, T.-L.; Wang, K., Structure of clusters and formation of amorphous calcium phosphate and hydroxyapatite: From the perspective of coordination chemistry. Cryst. Growth Des. 2013,13 (7), 3103-3109.

4.   Zhao, W.-H.; Gou, B.-D.; Zhang, T.-L.; Wang, K., Lanthanum chloride bidirectionally influences calcification in bovine vascular smooth muscle cells. J. Cell. Biochem. 2012,113 (5), 1776-1786.

5.   Bian, S.; Du, L.-W.; Gao, Y.-X.; Huang, J.; Gou, B.-D.; Li, X.; Liu, Y.; Zhang, T.-L.; Wang, K., Crystallization in aggregates of calcium phosphate nanocrystals: A logistic model for kinetics of fractal structure development. Cryst. Growth Des. 2012,12 (7), 3481-3488.

6.   Wang, C.-G.; Liao, J.-W.; Gou, B.-D.; Huang, J.; Tang, R.-K.; Tao, J.-H.; Zhang, T.-L.; Wang, K., Crystallization at multiple sites inside particles of amorphous calcium phosphate. Cryst. Growth Des. 2009,9 (6), 2620-2626.

7.   Shi, Y.-L.; Wang, L.-W.; Huang, J.; Gou, B.-D.; Zhang, T.-L.; Wang, K., Lanthanum suppresses osteoblastic differentiation via pertussis toxin-sensitive G protein signaling in rat vascular smooth muscle cells. J. Cell. Biochem. 2009,108, 1184-1091.

8.   Wang, C.; Zhang, Q.; Gou, B.-D.; Zhang, T.-L.; Wang, K., Differentiation-stimulating potency of differentiated HL60 cells after drug treatment. Biomed. Pharmacother. 2014, 68 (5), 581-588.

9.   Wang, L. W.; Shi, Y. L.; Wang, N.; Gou, B. D.; Zhang, T. L.; Wang, K., Association of oxidative stress with realgar-induced differentiation in human leukemia HL-60 cells. Chemotherapy 2009, 55 (6), 460-467.

10. Wang, N.; Wang, L.-W.; Gou, B.-D.; Zhang, T.-L.; Wang, K., Realgar-induced differentiation is associated with MAPK pathways in HL-60 cells. Cell Biol. Intl. 2008, 32, 1497-1505.

11. Luo, L.-Y.; Huang, J.; Gou, B.-D.; Zhang, T.-L.; Wang, K., Induction of human promyelocytic leukemia HL-60 cell differentiation into monocytes by arsenic sulphide: Involvement of serine/threonine protein phosphatases. Leuk. Res. 2006, 30, 1399-1405.

12. Gou, B.-D.; Liu, Y.; Gao, Y.-X.; Tang, K.; Zheng, L.; Zhao, Y.-D.; Zhang, T.-L.*, Ex vivo detection of calcium phosphate and calcium carbonate in rat blood serum. J. Struct. Biol. 2019, 205 (1), 41-47.

13. Fan, H.-X.; Gou, B.-D.; Gao, Y.-X.; Wu, G.; Zhang, T.-L.*, Pseudo-equilibrium equation of calcium phosphate precipitation from aqueous solution. Phys. Chem. Chem. Phys. 2019, 21 (39), 22057-22066.

14. Zhang, Q.; Liu, Y.; Gou, B.-D.; Zheng, L.; Gao, Y.-X.; Zhang, T.-L.*, Quantitative chemical relations at pseudo-equilibrium in amorphous calcium phosphate formation. RSC Advances 2016, 6 (104), 102710-102723.