Xiao-wei Wang : Associate Professor
Department of Chemical Biology, School of Pharmaceutical Sciences,
Tel: 010-82805203
Email: xiaoweiwang@bjmu.edu.cn
Teaching Experience
1. Instructed the organic chemistry experiments
2. Teaching Organic Chemistry as an undergraduate curriculum
3. Instructed the M.S. students’ dissertations
Research Interests
Study on the Antivirus Drugs, especially on the design, synthesis and biological evaluation of single and dual inhibitors of HIV virus.
Four Chinese invention patents were applied. More than 20 papers have been published and some of them have been indexed by SCI.
Publications
1. The design and synthesis of 9-phenylcyclohepta[d]pyrimidine-2, 4- dione derivatives as potent non- nucleoside inhibitors of HIV reverse transcriptase. Organic & Biomolecular Chemistry 2006, 4, 3252–3258
2. Yang Huang？, Xiaowei Wang？, Xiaoling Yu, Lin Yuan, Ying Guo, Weisi Xu, Tiejun Liu, Junyi Liu, Yiming Shao* and Liying Ma*, Inhibitory activity of 9-phenylcyclohepta[d]pyrimidinedione derivatives against different strains of HIV-1 as non-nucleoside reverse transcriptase inhibitors . Virology Journal 2011, 8:230
3. Li Li, Liying Ma, Xiaowei Wang,* Junyi Liu*, New efficient and flexible synthetic route to Emivirine and its analogs. Journal of Heterocyclic Chemistry, 2011 (in published)
4. Wenjing Chen, Wujie Li, Xiaomei Ling, Xiaowei Wang, Junyi Liu. Study on the interaction between HIV reverse transcriptase and its non-nucleoside inhibitor nevirapine by capillary electrophoresis. Journal of Chromatography B. 2010, 878: 1714–1717
5. Xiaowei Wang , Yanli Chen ; Ying Guo ; Amin Li ; Xiaoyan Mab; Junyi Liu, Synthesis of 1-(Alkyl)-5-Dimethylamino-6- Phenethyluracils as Potent Non- nucleoside HIV-1 RT Inhibitors Synthetic Communications 37: 2421–2431, 2007
6. Libo Gao ; Shigan Fu; Hui Li; Xiaowei Wang; Junyi Liu ;Han Liu; Liyuan Guo; Xinhua Liu; Mengsen Li; Michael A. McNutt; Gang Li, Pyrimidone derivative inhibits simian immunodeficiency virus-induced apoptosis of CEM x174 cells, Cell Biology International 33 (2009) 207-216
7. Xiao Lu, Yanli Chen, Ying Guo, Zhenming Liu, Yawei Shi, Yang Xu, Xiaowei Wang and Junyi Liu, The Design and Synthesis of N-1 alkylated 5-aminoaryalkyl substituted 6-methyluracils as potential non-nucleoside HIV-1 RT Inhibitors Bioorganic Medicinal Chemistry 15 (2007) 7399–7407
8. Hua Qin, Jianfang Zhang, Chang Liu, Ying Guo, Siwei Zhang, Zhili Zhang, Xiaowei Wang, Liangren Zhang, Junyi Liu, Synthesis and biological evaluation of novel 2-arylalkylthio-4-amino-6-benzyl pyrimidines as potent HIV-1 non-nucleoside reverse transcriptase inhibitors, Bioorganic Medicinal Chemistry Letter 2009.04.051
9. Hua Qin, Chang Liu, Ying Guo, Ruiping Wang, Jianfang Zhang, Liying Ma, Zhili Zhang, Xiaowei Wang, Yuxin Cui, Junyi Liu. Synthesis and biological evaluation of novel C5 halogen-functionalized S-DABO as potent HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry 2010, 18: 3231–3237.
10. Xiaowei Wang, Yu Gao, Yang Xu, Li Li, Zhili Zhang, Junyi Liu. An efficient preparation of a photolabile agent MNI-glu by regioselective nitration of 4-methoxyindoline derivative. Synthetic Communications 2009, 39(22); 4030-4038
11. Yanli Chen, Ying Guo, Hua Yang, Xiaowei Wang* and Junyi Liu, Synthesis of l-(Alkoxymethyl)-5-benzyl-6-methyluracil as Potential Non-nucleoside HIV-1 RT Inhibitors Synthetic Communications 36: 2913–2920, 2006
12. Li A-min, Wang Xiao-wei, Zhang Zhi-li, Cheng Zhi-jian and Liu Jun-yi. Regioselective Deprotection of 1,3-Dibenzyl-5-(N,N-dimethylamino)-6-phenylethyluracil. Chemical Research, Chinese University. 2008, 24(6): 1-4
13. Xu Yang, YANG Hua, CHEN Yan-li, LIU Jun-yi, WANG Xiao-wei, Study on the regioselective alkylation of 2-thiopyrimidine Journal of Pharmaceutical Sciences 2007, 2, 125-127
14. Zhili Zhang, Jun Wu, Fuxiang Ran, Ying Guo, Ran Tian, Shouxin Zhou, Xiaowei Wang, Zhenming Liu, Liangren Zhang, Jingrong Cui,* Junyi Liu,* Novel 8-deaza-5,6,7,8-tetrahydroaminopterin derivatives as dihydrofolate inhibitor: Design, synthesis and antifolate activity，European Journal of Medicinal Chemistry 44 (2009) 764-771
