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Ge Zemei


Zemei GeAssociate Professor.

Department of Chemical Biology, School of Pharmaceutical Sciences

Tel: +86-10-82801504  


Teaching courses: Organic Chemistry


Research interests:

1.Study on the design, synthesis and biological function of heterocyclic compounds. 2.Organic synthetic methodology.

More than 40 papers have been published and most of them have been indexed by SCI. Six Chinese invention patents were applied.

Representative Publications:

1. Ri-Dong Li, Xin Zhang, Qiao-Yan Li, Ze-Mei Ge*, Run-Tao Li* ,Novel EGFR inhibitors prepared by combination of dithiocarbamic acid esters and 4-anilinoquinazolines. Bioorg.Med. Chem. Lett., 2011, 21, 3637–3640.

2. Wang, Junfeng; Qi, Chao; Ge, Zemei*; Cheng, Tieming; Li, Runtao*. Efficient direct asymmetric vinylogous Michael addition reactions of ?g -butenolides to chalcones catalyzed by vicinal primary-diamine salts Chem. Commun., 2010, 46, 2124–2126 .

3. Wang, Junfeng; Li, Qin; Qi, Chao; Liu, Yi; Ge, Zemei*; Li, Runtao*. Primary 1,2-diamine catalysis III: an unexpected domino reaction for the synthesis of multisubstituted cyclohexa-1,3-dienamines. Organic & Biomolecular Chemistry, (2010), 8(19),  4240-4242.

4. Wang, Junfeng; Wang, Xin; Ge, Zemei*; Cheng, Tieming; Li, Runtao*. Highly enantioselective Michael addition of cyclopentanone with chalcones via novel di-iminium mechanism. Chem. Commun., 2010, 46, 1751-1753 .

5. MENG LEI, SHUAI XIA, JUNFENG WANG, ZEMEI GE,* TIEMING CHENG, AND RUNTAO LI*An Ef?cient Dipeptide-Catalyzed Direct Asymmetric Aldol Reaction of Equimolar Reactants in Solid MediaCHIRALITY, 22:580-586 (2010).

6. Fang-bin Han,Ze-mei Ge,*Tie-ming Cheng,Run-tao Li* ,Novel One-Pot, Four-Component Synthesis of 3-Alkyldithiocarbonyl-oxazolidines from Aminoethanols, Ketones, Carbon Disulfide, and Halides, Synlett., 2009, 4, 648-650.

7. Zhong-qing Wang, Ze-mei Ge,* Tie-ming Cheng, Run-tao Li*, Synthesis of Highly Substituted Pyridines via a One-Pot, Three-Component Cascade Reaction of Malononitrile with Aldehydes and S-Alkylisothiouronium Salts in Water, Synlett., 2009, 7, 2020-2022.

8. Jun-feng Wang, Meng Lei, Qin Li, Ze-mei Ge,* Xin Wang, Run-tao Li*, A novel and ef?cient direct aldol condensation from ketones and aromatic aldehydes catalyzed by proline–TEA through a new pathway, Tetrahedron.65(2009), 4826-4833

9. ZHU, Jirang(朱继让), LI, Ridong(李日东), GE, Zemei*(葛泽梅), CHENG, Tieming(程铁明), LI, Runtao*(李润涛),  Synthesis of β-Hydroxy Sulfides via Thiolysis of Epoxides Using S-Alkylisothiouronium Salts as Thiol Equivalents in Basic Aqueous Medium, Chinese Journal of Chemistry, 2009, 27, 791-796.

10. WANG, Zhongqing(王仲清), GE, Zemei*(葛泽梅), CHENG, Tieming(程铁明), LI, Runtao*(李润涛), An Efficient Four-Component, One-Pot Synthesis of  Poly-Substituted Pyrimidines in Water, Chinese Journal of Chemistry, 2009, 27, 834-838.

11. XuYan, Ze-Mei Ge*,Tie-Ming Cheng and Run-Tao Li*, One-pot synthesis of 1,3,4-oxadiazole-5-thioethers in water, Journal of Chinese Pharmaceutical Sciences 17 (2008 ) 277-280.

12. Song-wen Lin,a Qi Sun,a Run-tao Li,*a,b Tie-ming Cheng,a Ze-mei Ge*a, Potassium Phosphate Promoted Aza-Markovnikov Addition of N-Heterocycles to Vinyl Esters. Synthesis, 2007, 13, 1933-1938.

13. Yan Zhao,a Ze-Mei Ge,*a Tie-Ming Cheng,a Run-Tao Li*a,b, Thia-Michael Addition Using Cheap and Odorless S-Alkylisothiouronium Salts as Thiol Equivalents in Water. Synlett.,  2007, 10, 1529-1532.

14. Qi Sun, Run-Tao Li, Wei Guo, Jing-Rong Cui, Tie-Ming Cheng and Ze-Mei Ge,* Novel class of cyclophosphamide prodrug: Cyclophosphamide spiropiperaziniums (CPSP), Bioorganic & Medicinal Chemistry Letters, 2006, 16, 3727-3730.

15. GE, Ze-Mei, LI, Qin, ZHENG, Shao-Jun, CHENG, Tie-Ming, CUI, Yu-Xin, LI, Run-Tao*, Facile One-pot Synthesis of Ethyl 3-Alkyl-4-hydroxy-2-thioxothiazolidine-4-carboxylates, Chinese Journal of Chemistry, 2006, 24, 381-385.

16. Ze-mei Ge, Jia-ling Cui, Yan-ling Wang, Tie-ming Cheng, Run-tao Li*. A mild and efficient synthesis of 4, 5-disubstituted 3-amino-4-hydroxythiazolidine-2-thiones and S, N- disubstituted 1, 3, 4- thiadiazole-2-thiones. Synthesis, 2004, 8, 1257-1261.