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Li Runtao



Runtao Li   Professor  

Chemical Biology and Medicinal Chemistry

Phone:   010-82801504

Fax:     010-82716956   



B.Sc.  Zhengzhou University, 1981.12;

M.Sc.  Zhengzhou University, 1988.6;

Ph.D.  Dalian University of Technology, 1993.6;


2000 ~          Professor, School of Pharmaceutical Sciences, Peking University;

1996~2000       Associate professor, School of Pharmaceutical Sciences, Beijing Medical University

1993.12~1995.12  Postdoctoral fellow, School of Pharmaceutical Sciences, Beijing Medical University

1988.8~1993.12  Lecturer and Associate professor, Department of Chemistry, Zhengzhou University;

1982.1~1985.8   Teacher, Department of Chemistry, Henan University

1997.11~1998.3  Advanced Visiting Scholar, Pharmaceutical Institute, Bonn University, Germany.

2002.1~2002.9,  Visiting professor, Medinox. Inc., USA 

Teaching courses: Advanced Organic Synthesis, Heterocyclic Chemistry

Research interest: Study on the synthesis and biological function of heterocyclic compounds; Organic synthetic methodology;

Representative Publications since 2003:

1.      Junfeng Wang, Qin Li, Chao Qi, Yi Liu, Zemei Ge,* and Runtao Li*, Primary 1,2-diamine catalysis III: An unexpected domino reaction for the synthesis of multisubstituted cyclohexa-1,3-dienamines, Org. Biomol. Chem., 2010, 8, 4240 - 4242

1.      Junfeng Wang, Xin Wang, Zemei Ge,* Tieming Cheng, Runtao Li.* Highly enantioselective Michael addition of cyclopentanone with chalcones via novel di-iminium mechanism. Chem. Commun., 2010, 46, 1751-1753.

2.      Junfeng Wang, Chao Qi, Zemei Ge,* Tieming Cheng, Runtao Li.* Efficient direct asymmetric vinylogous Michael addition reactions of g-butenolides to chalcones catalyzed by vicinal primary-diamine salts. Chem. Commun., 2010, 46, 2124-2126.

3.      Xin Ai, Xin Wang*, Jin-ming Liu, Ze-mei Ge, Tie-ming Cheng, Run-tao Li* An effective Aza-Michael addition of aromatic amines to electron-de?cient alkenes in alkaline Al2O3. Tetrahedron, 2010, 66 (29), 5373-5377.

4.      Fang-bin Han, Ze-mei Ge, Tie-ming Cheng, Run-tao Li*. Novel One-Pot, Four-Component Synthesis of 3-Alkyldithiocarbonyl-oxazolidines from Aminoethanols, Ketones, Carbon Disulfide, and Halides. Synlett, 2009, 4, 648-650.

5.      Shuai Xia, Xin Wang,* Ze-mei Ge, Tie-ming Cheng, Run-tao Li*. An ef?cient synthesis of aryldithiocarbamic acid esters from Michael addition of electron-de?cient alkenes with arylamines and CS2 in solid media alkaline Al2O3, Tetrahedron, 2009, 65, 1005-1009.

6.      Jun-feng Wang, Meng Lei, Qin Li, Ze-mei Ge, Xin Wang, Run-tao Li*. A novel and ef?cient direct aldol condensation from ketones and aromatic aldehydes catalyzed by proline–TEA through a new pathway. Tetrahedron, 2009, 65, 4826-4833.

7.      Zhong-qing Wang, Ze-mei Ge, Tie-ming Cheng, Run-tao Li*. Synthesis of Highly Substituted Pyridines via a One-Pot, Three-Component Cascade Reaction of Malononitrile with Aldehydes and S-Alkylisothiouronium Salts in Water. Synlett, 2009, 4, 648-650.

8.      Yongqiang Zhu, Shuyang Yao, Bo Xu, Zemei Ge, Jingrong Cui, Tieming Cheng, Runtao Li. Design, synthesis and biological evaluation of tripeptide boronic acid proteasome inhibitors. Bioorg. Med. Chem. 2009, 17, 6851-6861.

9.      Qi Sun, Cai-Qin Yue,a Jia Ye, Chang-Ling Li, Tie-Ming Cheng, Run-Tao Li*. Unique spirocyclopiperazinium salt III: Further investigation of monospirocyclo- piperazinium (MSPZ) salts as potential analgesics. Bioorg. Med. Chem. Lett., 2007, 17, 6245-6249.

10.   Song-wen Lin, Qi Sun, Run-tao Li.* Tie-ming Cheng, Ze-mei Ge*, Potassium Phosphate Promoted Aza-Markovnikov Addition of N-Heterocycles to Vinyl Esters. Synthesis, 2007, 13, 1933-1938.

11.   Yan Zhao, Ze-Mei Ge, Tie-Ming Cheng, Run-Tao Li*, Thia-Michael Addition Using Cheap and Odorless S-Alkylisothiouronium Salts as Thiol Equivalents in Water. Synlett, 2007, 10, 1529-1532.

12.   Meng Lei, Lanxiang Shi, Gong Li, Shilv Chen, Weihai Fang, Zemei Ge, Tieming Cheng, Runtao Li*, Dipeptide-catalyzed direct asymmetric aldol reactions in the presence of water. Tetrahedron, 2007, 63, 7892-7898.

13.   Ang Li, Xin Wang, Cai-Qin Yue, Jia Ye, Chang-Ling Li, Run-Tao Li*. Unique spirocyclopiperazinium salt. Part 4: Modification of dispirocyclo- piperazinium (DSPZ) salts as analgesicsBioorg. Med. Chem. Lett., 2007, 17, 5078-5081.

14.   Xueling Hou, Zemei Ge, Tingmin Wang, Wei Guo, Jingrong Cui, Tieming Cheng, Chingshan Lai, Runtao Li*. Dithiocarbamic acid esters as anticancer agent. Part 1: 4-Substituted-piperazine-1-carbodithioic acid 3-cyano-3,3-diphenyl-propyl esters, Bioorg. Med. Chem. Lett., 2006, 16, 4214-4219.

15.   Chuan-Xin Zhang, Yi-Qiang Wang, Yong-Sheng Duan, Ze-Mei Ge, Tie-Ming Cheng, Run-Tao Li,* Selective Michael addition of pyrrole to conjugated alkenes catalyzed by Cr3+-Catsan and ZnCl2, Catalysis Communications, 2006, 7, 534-537.

16.   Wang, Xin; Sha, Yaowu; Hou, Xueling; Li, Runtao*, Electrospray ionization tandem mass spectrometric analysis of fragmentation patterns of dithiocarbamate derivatives. Rapid Commun. Mass Spectrom., 2006, 20(4), 719-722.

17.   Zhang, Chuan-Xin; Ge, Ze-Mei; Cheng, Tie-Ming; Li, Run-Tao*. Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594. Bioorg. Med. Chem. Lett., 2006, 16, 2013-2016.

18.   Zhu, Yong-Qiang; Pei, Jian-Feng; Liu, Zhen-Ming; Lai, Lu-Hua; Cui, Jing-Rong; Li, Run-Tao*. 3D-QSAR studies on tripeptide aldehyde inhibitors of proteasome using CoMFA and CoMSIA methods. Bioorg. Med. Chem. 2006, 14(5), 1483-1496..

19.   Qi Sun, Run-Tao Li, Wei Guo, Jing-Rong Cui, Tie-Ming Cheng and Ze-Mei Ge,* Novel class of cyclophosphamide prodrug: Cyclophosphamide spiropiperaziniums (CPSP), Bioorg. Med. Chem. Lett., 2006, 16, 3727-3730.