Wang Jing
Tenure-Tracked Assistant Professor
Research Areas
Chemical Biology
Medical Chemistry
Education & Positions
● Soochow University, B.S., 2000-2004.
● Shanghai Institute of Organic Chemistry, CAS, Ph.D., 2004-2009.
● University of Chicago, Department of Chemistry, Howard Hughes Medical Institute, Postdoctoral Fellow, 2009-2015.
● Peking University, School of Pharmaceutical Sciences, Department of Chemical Biology, Principal Investigator, Assistant Professor, 2016-now.
Awards
● 2009, Eli Lilly Asia Outstanding Graduate Thesis Award 1st prize.
Research Interests
Our research is interested in a broad range of chemical biology, bioinorganic chemistry, epigenetics and medical chemistry. The ability to regulate essential or toxic metal ion concentrations is critical for cell survival.Recently, we developed a small molecule that blocks copper trafficking inside mammalian cells through binding to the copper-trafficking proteins. The treatment with this small molecule selectively inhibits the growth and proliferation of several types of human cancer cells in animal models. Next we plan to further study the trafficking mechanism of these copper chaperones in cancer cells, especially those functions in nucleus and mitochondrion, by combining chemical biology, bioinformatics and molecular biology. In addition, ‘Biologic gases’ are thought to diffuse freely across biologic membranes, acting in a variety of functional capacities in biological signaling. In the past, we developed a genetically encoded fluorescent probes for carbon monoxide (CO) imaging in live cells. More recently, our laboratory constructed a biosensor for GTP/GDP ratio imaging in neuron cells. We will continue to develop and engineer robust and sensitive biosensors for detecting metabolites in cancer and neuron cells, to reveal the spatiotemporal specificity of these small molecules. Meanwhile, we are seeking to develop some chemical-lable sequencing technologies for genome-wide identification of 5mC, 5hmC and 5caC, to dissect the functional roles of these DNA modifications in clinical trail.
Grants & fundings
● National Basic Research Foundation of China (Grant No. 2017YFA0505202).
● National Natural Science Foundation of China (Grant No. 21672014).
Publications &Patents
1. Wang, J.; Luo, C.; Shan, C.L.; You, Q.C.; Lu, J.Y.; Elf, S.; Zhou, Y.; Wen, Y.; Xie, Y.X.; Vinkenborg, J.L.; Fan, J.; Kang, H.B.; Lin, R.T.; Han, D.L.; Karpus, J.; Chen, S.J.; Ouyang, S.S.; Luan, C.H.; Zhang, N.X.; Merkx, M.; Liu, H.; Chen, J.; Jiang, H.L.; He, C. Inhibition of human copper trafficking by small molecule significantly attenuates cancer cell growth. Nat. Chem. 2015, 7, 968-979.
2. Wang, J.; Karpus, J.; Zhao, B. S.; Luo, Z.; Chen, P. R.; He, C. A selective fluorescent probe for carbon monoxide imaging in living cells. Angew. Chem. Int. Ed. 2012, 51, 9652-9656.
3. Song, C.X.; Szulwach, K.E.; Fu, Y.; Dia, Q.; Yi, C.; Li, X.; Li, Y.; Chen, C.H.; Zhang, W.; Jian, X.; Wang, J.; Zhang, L.; Looney, T.J.; Zhang, B.; Godley, L.A.; Hicks, L.M.; Lahn, B.T.; Jin, P.; He, C. Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat. Biotechnol. 2011, 29, 68-72.
4. He, Chuan; Wang, Jing; Jiang, Hualiang; Luo, Cheng; Liu, Hong; Lu, Junyan. U.S. Provisional Patent No. WO2014/116859: “Methods and Compositions for Inhibiting Human Copper Trafficking Proteins Atox1 and CCS”.
