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Li Houhua


Houhua Li

Tenure-Track Assistant Professor

Research Areas

Natural Product Chemistry

Chemical Biology

Education & Positions

Peking University, School of Pharmaceutical Sciences, B.S., 2002-2006.

Peking University, School of Pharmaceutical Sciences, M.S., 2006-2009.

National Institute of Biological Sciences, Beijing (NIBS), Research Assistant, 2009-2011

University of Geneva, Ph.D., 2011-2016

Max Planck Institute of Molecular Physiology, Postdoctoral Fellow, 2016-2019

Peking University, School of Pharmaceutical Sciences, Tenure-Track Assistant Professor, 2019-

Peking University, State Key Laboratory of Natural and Biomimetic Drugs, PI, 2019-


Swiss National Science Foundation (SNSF) Early Postdoc. Mobility fellowship, 2016-2018

The Reaxys PhD Prize Finalist, 2016

Research interests

1. Total Synthesis of Bioactive Natural Products

2. Cellular Targets Identification and Elucidation of the Mechanism of Action (MoA) of Natural Products

3. Natural Product Research for Translational Medicine and Therapeutics

Selected Publications

1. B. Hong, W. Liu, J. Wang, J. Wu, Y. Kadonaga, P.-J. Cai, H.-X. Lou, Z.-X. Yu, H. Li,* X. Lei,* Photoinduced Skeletal Rearrangements Reveal Radical-Mediated Synthesis of Terpenoids. Chem 2019, DOI: 10.1016/j.chempr.2019.04.023.

2. H. Li, R. Gontla, J. Flegel, C. Merten, S. Ziegler, A. P. Antonchick,* H. Waldmann*, Enantioselective Formal C(sp3)-H Bond Activation in the Synthesis of Bioactive Spiropyrazolone Derivatives. Angew. Chem. Int. Ed. 2019, 58, 307-311.

3. H. Li, C. Mazet*, Iridium-Catalyzed Selective Isomerization of Primary Allylic Alcohols. Acc. Chem. Res. 2016, 49, 1232-1241.

4. B. Hong, C. Li, Z. Wang, J. Chen, H. Li,* X. Lei*, Enantioselective Total Synthesis of (-)-Incarviatone A. J. Am. Chem. Soc. 2015, 137, 11946-11949.

5. H. Li, C. Mazet*, Catalyst-Directed Diastereoselective Isomerization of Allylic Alcohols for the Stereoselective Construction of C(20) in Steroid Side Chains: Scope and Topological Diversification. J. Am. Chem. Soc. 2015, 137, 10720-10727.