Houhua Li
Tenure-Track Assistant Professor
Research Areas
Natural Product Chemistry
Chemical Biology
Education & Positions
Peking University, School of Pharmaceutical Sciences, B.S., 2002-2006.
Peking University, School of Pharmaceutical Sciences, M.S., 2006-2009.
National Institute of Biological Sciences, Beijing (NIBS), Research Assistant, 2009-2011
University of Geneva, Ph.D., 2011-2016
Max Planck Institute of Molecular Physiology, Postdoctoral Fellow, 2016-2019
Peking University, School of Pharmaceutical Sciences, Tenure-Track Assistant Professor, 2019-
Peking University, State Key Laboratory of Natural and Biomimetic Drugs, PI, 2019-
Awards
Swiss National Science Foundation (SNSF) Early Postdoc. Mobility fellowship, 2016-2018
The Reaxys PhD Prize Finalist, 2016
Research interests
1. Total Synthesis of Bioactive Natural Products
2. Cellular Targets Identification and Elucidation of the Mechanism of Action (MoA) of Natural Products
3. Natural Product Research for Translational Medicine and Therapeutics
Selected Publications
1. B. Hong, W. Liu, J. Wang, J. Wu, Y. Kadonaga, P.-J. Cai, H.-X. Lou, Z.-X. Yu, H. Li,* X. Lei,* Photoinduced Skeletal Rearrangements Reveal Radical-Mediated Synthesis of Terpenoids. Chem 2019, DOI: 10.1016/j.chempr.2019.04.023.
2. H. Li, R. Gontla, J. Flegel, C. Merten, S. Ziegler, A. P. Antonchick,* H. Waldmann*, Enantioselective Formal C(sp3)-H Bond Activation in the Synthesis of Bioactive Spiropyrazolone Derivatives. Angew. Chem. Int. Ed. 2019, 58, 307-311.
3. H. Li, C. Mazet*, Iridium-Catalyzed Selective Isomerization of Primary Allylic Alcohols. Acc. Chem. Res. 2016, 49, 1232-1241.
4. B. Hong, C. Li, Z. Wang, J. Chen, H. Li,* X. Lei*, Enantioselective Total Synthesis of (-)-Incarviatone A. J. Am. Chem. Soc. 2015, 137, 11946-11949.
5. H. Li, C. Mazet*, Catalyst-Directed Diastereoselective Isomerization of Allylic Alcohols for the Stereoselective Construction of C(20) in Steroid Side Chains: Scope and Topological Diversification. J. Am. Chem. Soc. 2015, 137, 10720-10727.
