Tian Chao

Assistant Professor

Research Areas

Medicinal Chemistry

Education & Positions

Peking University (PKU), B.S., 2006.

Peking University (PKU), M.S., 2008.

Peking University (PKU), Ph.D., 2011.

Peking University, Assistant Professor 2011-.

Faculty Accolades

Excellent Teacher Award of Peking University Health Science Center2018.

Excellent Teacher Award of Peking University Health Science Center2014. 

Research Interests

Our research interests are primarily in the fields of medicinal chemistry and chemical biology. Our work focuses on the discovering of novel anti-cancer agents targeting CHK1 (checkpoint kinase 1), tubulin or dual CHK1&MK2 (mitogen-activated protein kinase-activated protein kinase 2) against chemotherapy-resistant and refractory cancers. Some research topics we have been working on recently:

●  Checkpoint kinase 1 (CHK1) inhibitors as anti-cancer potentiating agents

●  Novel anti-tubulin agents

●  Dual CHK1&MK2 inhibitors as anti-KRAS-mutant cancer drugs

Grants and fundings

National Natural Science Funds for Youth of China No. 21302007

Project Name: Design, Synthesis and Evaluation of Novel non-ATP Competitive Selective CHK1 inhibitors as Oncotherapy Sensitizer and Anti-Resistance Agents Project

Principle investigator

Publications

1. Chao Tian*, Zifei Han, Yuanxin Li, Meng Wang, Jiajia Yang, Xiaowei Wang, Zhili Zhang, Junyi Liu* Synthesis and biological evaluation of 2,6-disubstituted-9H-purine, 2,4-disubstituted-thieno[3,2-d]pyrimidine and -7H-pyrrolo[2,3-d] pyrimidine analogues as novel CHK1 inhibitors European Journal of Medicinal Chemistry 2018; 151: 836-848.

2. Chao Tian, Meng Wang, Zifei Han, Fang Fang, Zhili Zhang, Xiaowei Wang, Junyi Liu* Design, synthesis and biological evaluation of novel 6-substituted pyrrolo [3,2-d] pyrimidine analogues as antifolate antitumor agents European Journal of Medicinal Chemistry 2017; 138: 630-643.

3. Meng Wang, Jiajia Yang, Mengmeng Yuan, Liangmin Xue, Hao Li, Chao Tian, Xiaowei Wang, Junyi Liu*, Zhili Zhang* Synthesis and antiproliferative activity of a series of novel 6-substituted pyrido[3,2-d]pyrimidines as potential nonclassical lipophilic antifolates targeting dihydrofolate reductase. European Journal of Medicinal Chemistry, 2017; 128, 88-97.

4. Chao Tian, Zhili Zhang, Shouxin Zhou, Mengmeng Yuan, Xiaowei Wang, Junyi Liu* Synthesis, Antifolate and Anticancer Activities of N5-substituted 8,10-dideazatetrahydrofolate analogues. Chemical Biology & Drug Design, 2016; 87: 444–454.

5. Xianling Ning, Ying Guo, Xiaowei Wang, Xiaoyan Ma, Chao Tian, Xueqi Shi, Renzong Zhu, Can Cheng, Yansheng Du, Zhizhong Ma, Junyi Liu* Design, Synthesis, and Biological Evaluation of (E)-3, 4-Dihydroxystyryl Aralkyl Sulfones and Sulfoxides as Novel Multifunctional Neuroprotective Agents. Journal of Medicinal Chemistry, 2014, 57(10), 4302-4312.