Education:

1997-2000    Department of Pharmaceutical Chemistry, The University of Kansas, Postdoctor .

1994-1996    School of Pharmaceutical Sciences, Beijing Medical University, Postdoctor.

1988-1994    Department of Chemistry, Peking University, Ph.D

1984-1988    Department of Chemistry, Peking University, B.S.

 

Professional：

2006-2010  Vice dean of Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University Health Science Center.

2003-todate Professor, School of Pharmaceutical Sciences, Peking University Health Science Center.

2000-2003 Associate professor, School of Pharmaceutical Sciences, Peking University Health Science Center.

 

Research Interests：Studies of the molecular mechanisms of pharmacological and/or toxicological actions of metal ions for discovery of inorganic drugs, including: (1) metal-involved signal transduction in diabetes, cardiovascular and neural degenerative diseases; (2) ADMET properties of inorganic drugs and minerals in Traditional Chinese Medicines.

 

Selected publications：

(1)     Wei, Y, Zhang, C, Zhao, P, Yang, X, Wang, K, A new salicylic acid-derivatised kojic acid vanadyl complex: Synthesis, Characterization and Anti-diabetic Therapeutic Potential, J. Inorg. Biochem. 2011, 105: 1081–1085

(2)     Xia, Q., Feng, X., Huang, H., Du, L., Yang, X., Wang, K., Gadolinium-induced oxidative stress triggers endoplasmic reticulum stress in rat cortical neurons, J. Neurochem., 2011, 117: 38–47.

(3)     Zhou, X., Zeng, K., Wang, Q., Yang, X., and Wang, K. In vitro studies on dissolved substance of cinnabar: chemical species and biological properties, J Ethnopharmacol. 2010, 131, 196-202

(4)     Tian, XJ., Yang, XW., Yang, X., Wang, K., Studies of intestinal permeability of 36 flavonoids using Caco-2 cell monolayer model, Int. J. Pharm., 2009, 367: 58–64

(5)     Li, M, Li, Y, Chen, J, Wei, W, Pan, X, Liu, J, Liu, Q, Leu, W, Zhang, L, Yang, X, Lu, J, Wang, K, Copper ions inhibit S-Adenosylhomocysteine hydrolase by causing dissociation of NAD⁺ cofactor, Biochemistry, 2007, 46, 11451-11458.

(6)     Yu, S., Hu, J., Yang, X., Wang, K., Qian, ZM, La³⁺-Induced Extracellular Signal-Regulated Kinase (ERK) Signaling via a Metal-Sensing Mechanism Linking Proliferation and Apoptosis in NIH 3T3 Cells, Biochemistry, 2006, 45, 11217-11225.

(7)     Zhang, Y., Yang, X., Wang, K., Crans, D.C., The Permeability and Cytotoxicity of Insulin-mimetic Vanadium (III, IV, V)-Dipicolinate Complexes, J. Inorg. Biochem, 2006, 100: 80-97.

(8)     Yang, X.-G., Yang, X., Yuan, L., Wang, K., Crans, D.C., The Permeability and Cytotoxicity of Insulin-mimetic Vanadium Compounds, Pharm. Res., 2004, 21/6, 1026-1033.

(9)     Hu, J., Jia, X., Li, Q., Yang, X. and Wang, K. La³⁺ Binds to Ca²⁺ Sites of Calmodulin but Results in Altered Conformation and Kinetic Properties as Binding of Calmodulin to Mastoparan, Biochemistry, 2004, 43, 2688-2698.

(10)  Liu, H., Yuan, L., Yang, X., Wang, K., La³⁺, Gd³⁺ and Yb³⁺ induced changes in mitochondrial structure, membrane permeability, cytochrome C release and intracellular ROS level. Chem-Biol. Inter., 2003,146, 27-37.

 

(11)  Yang, X., Hu, Y., Yin, D.H., Turner, M.A., Wang, M., Borchardt, R.T., Howell, P.L., Kuczera, K. and Schowen, R.L., Catalytic strategy of S-adenosyl-l-homocysteine hydrolase: transition- state stabilization and the avoidance of abortive reactions. Biochemistry, 2003, 42, 1900-9.

(12)  Yang, X.; Ci, Y-X.; Chang, W-B., Time resolved fluorescence immunoassay with measurement of a europium chelate in solution: dissociation conditions and application for determination of Cortisol", Anal. Chem., 1994, 66, 2590-2594.