Zhongjun  Li：Ph.D.  Professor of Chemical Biology

Tel: +86-10-82801714

E-mail: zjli@bjmu.edu.cn

Address: Department of Chemical Biology, Peking University School of Pharmaceutical Sciences, 38 Xueyuan Road, Beijing 100191, P R China

Curriculum Vitae

Education

Sept.1982-July 1987, B.Sc. in Chemistry, Beijing Medical University, Beijing, China.

Sept.1987-July1 992, Ph.D. in Medicinal Chemistry, Beijing Medical University, Beijing, China.

Professional Experience

1999 ~present, Professor, School of Pharmaceutical Sciences, Peking University.

1994~1999, Associate Professor, School of Pharmaceutical Sciences, Beijing Medical University.

1992~1994, Lecturer, School of Pharmaceutical Sciences, Beijing Medical University.

Teaching

Current teaching includes a second year undergraduate lecture course on Organic Synthesis and a postgraduate lecture course on Carbohydrate Chemistry.

Research Interests

My group focuses on developing new glycosylation methods, novel methods and strategies for the rapid assembly of oligosaccharides, asymmetry synthesis and chiral synthesis based on carbohydrates. We constructed a functionally diverse library from carbohydrate-based substrates and investigated their structure-affect relationships recently. And we also aim to discover carbohydrate-based probes and drugs.

Selected publications since 2006

1. Bo Wang, Zhaojun Yin, Yangbing Li, Ting-Xiang Yang, Xiang-Bao Meng, Zhong-Jun Li, An Active Cobalt Catalyst for the Cleavage of Benzyl Ether, J. Org. Chem., 2011, DOI: 10.1021 /jo2018284.

2. Wenhe Zhong, Jun Yang, Xiangbao Meng, and Zhongjun Li, Diastereoselective Diacetoxylation

  of Alkenes Mediated by PhI(OAc)2/BF3•OEt2 System, J. Org. Chem., 2011, DOI: 10.1021/ jo201752y.

3. Shasha Li, Wenhe Zhong, Zhongjun Li, Xiangbao Meng, Unprecedented synthesis,invitro and in vivo anticancer evaluation of novel triazolonaphthalimide derivatives, Eur. J. Medicin. Chem., DOI: 10.1016/j.ejmech.2011.11.0.

4. Qing Ma, Sheng Sun, Xiang-Bao Meng, Shu-Chun Li, Zhong-Jun Li, Assembly of Homolinear

   α(1→2)-Linked Nonamannoside on Ion Liquid Support, J. Org. Chem., 2011, 76, 5652-5660.

5.Yunfeng Li, Yao Meng, Xiangbao Meng, Zhongjun Li, Stereoselective synthesis of polyoxygenated linear diaza-triquinanes via intramolecular 1, 3-dipolar cycloaddition of sugar-derived hex-5-enals, Tetrahedron, 2011, 67, 4002-4008.

6. Boyu Li, Gang Wang, Zhongjun Li, Xiangbao Meng, InCl3-Catalyzed Synthesis of C-Pyrrolyl

    Glycosides in water: Tandem Condensation of Aminosugars and 1, 3-Dicarbonyl Compounds through Carbocation Intermediates, Tetrahedron Lett., 2011, 52, 3891-3894.

7. Yan-Ping Li, Zhong-Jun Li, Xiang-Bao Meng, Highly diastereoselective conjugate addition of nitroalkanes to α, b-unsaturated sugar lactones for the efficient synthesis of chiral 2-pyrrolidones, Carbohydr. Res., 2011, 346, 1801-1808.

8. Zhao-Jun Yin, Bo Wang, Yang-Bing Li, Xiang-Bao Meng, Zhong-Jun Li, A Highly Efficient and Mild Method for Regioselective de-O-benzylation of Saccharides by Co2(CO)8-Et3SiH-CO Reagent System, Org. Lett., 2010, 12, 536-539.

9. Ming Zhong, Xiang-Bao Meng, Zhong-Jun Li, Synthesis of γ-aminobutyric acid analogs based

    on carbohydrate scaffolds, Carbohydr. Res., 2010, 345, 1099-1106.

10. Yang Yang, Yuetao Zhao, Tingting Yan, Min Yu, Yinlin Sha, Zhihui Zhao, Zhongjun Li, Design and fabrication of multivalent gal-containing quantum dots and study of its interactions with a sialo- glycoprotein receptor (ASGP-R), Tetrahedron Lett., 2010, 51, 4182- 4185.

11. Yang Yang, Min Yu, Tingting Yan, Zhihui Zhao, Yinlin Sha, Zhongjun Li, Characterization of

    multivalent lactose quantum dots and its application in carbohydrate-protein interactions study and cell imaging, Bioorg. Med. Chem., 2010, 18, 5234-5240.

12. Min Yu, Yang Yang, Rongcheng Han, Qiang Zheng, Lijun Wang, Yuankai Hong, Zhongjun Li,

  Yinlin Sha, Polyvalent Lactose-Quantum Dot Conjugate for Fluorescent Labeling of Live Leukocytes, Langmuir, 2010, 26, 8534-8539.

13. Bo-Yu Li, Zhong-Jun Li, Xiang-Bao Meng, InCl3-catalyzed asymmetric aza-Friedel- Crafts reaction of indoles with imines generated from O-pivaloylated β-D- galactosylamine, Carbohydr. Res., 2010, 345, 1708-1712.

14. Dong Han, Xiang-Bao Meng, Lin-Na Wang, Hong Liu, Yun Yao, Zhuo Wang, Zhen-Jun Yang,

    Zhongjun Li, Efficient synthesis of a series of novel fructose- based 3-acetyl-5-alkyl-2,3-dihydro-1,3,4-oxadiazole derivatives and studies of the reaction mechanism, Tetrahedron: Asymmestry., 2009, 20, 399-410.

15. Min Li, Wan Sun, Ya-ping Yang, Bo Xu, Wen-yuan Yi, Yan-xia Ma, Zhong-jun Li, Jing-rong Cui, In vitro anticancer property of a novel thalidomide analogue through inhibition of NF-kB activation in HL-60 cells. Acta Pharmacol. Sin., 2009, 30, 1-7.

16. Zhihui Zhao,Qing Li, Jiale Hu, Zhongjun Li, Jinghua Liu, Aihua liu,Peng Deng, Lin Zhang,Xiaowei Gong, Kesen Zhao, Shuangquan Zhang, Yong Jiang, Lactosyl derivatives function in a rat model of severe burn shock by acting as antagonists against CD11b of integrin on leukocytes, Glycoconj. J., 2009, 26, 173-188.

17. Gui-Hui Chen, Pan Pan, Ying Chen, Xiang-Bao Meng, Zhong-Jun Li, Selective deprotection

   of the Cbz amine protecting group for the facile synthesis of kanamycin A dimers linked at N-3′′ position, Tetrahedron, 2009, 65, 5922-5927.

18. Lin-Na Wang, Dong Han, Fei-Fei Xu, Xaing-Bao Meng, Zhong-Jun Li, Microwave-assisted

   efficient synthesis of glucose-based 3-acetyl-5-alkyl-2, 3-dihydro-1, 3, 4-oxadiazole derivatives catalyzed by sodium acetate, Carbohydr. Res., 2009, 344, 2113-2119.

19. Gui-Hui Chen, Pan Pan, Yun Yao, Ying Chen, Xiang-Bao Meng, Zhong-Jun Li, Regioselective

   Modification of Amino Groups in Aminoglycosides Based on Cyclic Carbamate Formation, Tetrahedron, 2008, 64, 9078-9087.

20. Xiang-Bao Meng, Dong Han, Su-Na Zhang, Wei Guo, Jing-Rong Cui, Zhongjun Li*. Synthesis and anti-inflammatory activity of N-phthalimidomethyl 2, 3- dideoxy- and 2,3-unsaturated glycosides, Carbohydr. Res. 2007, 342, 1169-1174.

21. Xiang-Bao Meng, Yun-Feng Li, Zhong-Jun Li, Acyl chloride/DABCO-promoted acetal migration of 1, 2:4, 5-O-isopropylidene-D-fructopyranose, Carbohydr. Res. 2007, 342, 1101-1104.

22. Zhao-Jun Yin, Qing Li, Xiangbao Meng, Zhongjun Li. Design and Synthesis of Novel Multivalent Mannosides Targeting Mannose Receptor, Carbohydr. Res., 2007, 342, 2729-2734.

23. Jia-Ning An, Xiang-Bao Meng, Zhong-Jun Li, A Facile Synthesis of 1, 6- Dideoxynojirimycin

   from L-Sorbose, Carbohydr. Res., 2006, 341, 2200-2203.

24. Meng-shen Cai, Zhong-jun Li, eds., Carbohydrate Chemistry, Chemical Industry Press, Beijing 2007.