李忠堂
电话：(010)-82801504(办公室)
E-mail: lizhongtang@bjmu.edu.cn
通讯地址：北京市海淀区学院路38号北京大学医学部药学楼505
个人简历：
2021-08 至 今, 北京大学, 药学院化学生物学系, 助理研究员（李中军教授课题组）
2017-07 至2021-07, 北京大学,药学院药物化学系, 博士后（张亮仁教授课题组）
2012-09 至2017-06, 中国人民解放军军事医学科学院, 药物化学, 博士
2008-09 至2012-06, 山东大学, 药学, 学士
主要从事专业为药物化学与化学糖生物学，研究方向为糖类药物的设计合成，主要针对病原体与宿主相互作用以其免疫微环境，开发基于糖类结构的糖类药物、糖疫苗、递送材料等，并对其作用机制进行研究。作为主持人承担国自然科学基金原创项目/青年项目、博士后基金面上项目等国家级项目。
代表论著：
1. Zongchao Zuo#; Limei Wang#; Shaozheng Wang#; Xinyu Liu; Dandan Wu; Zhangyi Ouyang, Ruoxi Meng; Yajun Shan; Shouguo Zhang; Tao Peng; Lin Wang*; Zhongtang Li*; Yuwen Cong*; Radioprotective effectiveness of a novel delta-tocotrienol prodrug on mouse hematopoietic system against 60Co gamma-ray irradiation through inducing granulocyte-colony stimulating factor production. European Journal of Medicinal Chemistry, 2024, 269, 116346.
2. Ao Sun; Zipeng Li; Yuchao Wang; Shuai Meng; Xiao Zhang; Xiangbao Meng; Shuchun Li; Zhongtang Li*; Zhongjun Li*; Stereocontrolled synthesis of α-3-deoxy-D-manno-oct-2-ulosonic acid (α-Kdo) glycosides using C3-p-tolylthio-substituted kdo donors: access to highly branched kdo oligosaccharides, Angew Chem Int Ed Engl. 2024;63(2): e202313985.
3. Zhongtang Li#*;Xiaoyu Sun#; Yuchao Wang#; Ao Sun#; Linbo Fu; Tongtong Geng; Zihui Zhang; Ximin Lv; Qian Wang; Jing Wang; Baodi Gou; Xiangbao Meng; Zhongjun Li*; Anti-inflammatory glycosaminoglycan oligosaccharides from colwellia psychrerythraea 34H capsule: synthesis and biological evaluation, CCS Chemistry, 2023.DOI: 10.31635/ccschem.023.202303364.
4. Dake Liu; Shuyan Liu; Fanlei Hu*; Zhongtang Li*; Zhongjun Li*; N-Glycosylated type II collagen peptides as therapeutic saccharide vaccines for rheumatoid arthritis, Chinese Chemical Letter, 2024;35(5): 108762.
5. Zhongtang Li#; Fan Fang#; Yiyan Li#; Xuehui Lv; Ruqiu Zheng; Peili Jiao; Yuxi Wang; Guiwang Zhu; Zefang Jin; Xiangqing Xu; Yinli Qiu; Guisen Zhang; Zhongjun Li; Zhenming Liu; Liangren Zhang; Carbazole and tetrahydro-carboline derivatives as dopamine D3 receptor antagonists with the multiple antipsychotic-like properties, Acta Pharmaceutica Sinica B, 2023, 13(11): 4553-4577.
6. Zhongtang Li#; Guiwang Zhu#; Xiaoang Liu#; Tongfei Gao; Fan Fang; Xiaodong Dou; Yiyan Li; Ruqiu Zheng; Hongwei Jin; Liangren Zhang*; Zhenming Liu*; Lihe Zhang; The structure-based optimization of 3-substituted indolin-2-one derivatives as potent and isoform-selective c-Jun Nterminal kinase 3 (JNK3) inhibitors and biological evaluation,European Journal of Medicinal Chemistry, 2023, 250: 115167.
7. Hesuyuan Huang#; Xuyang Ding#; Dan Xing; Jianhao Lin; Zhongtang Li*; Jianhao Lin*; Hyaluronic acid oligosaccharide derivatives alleviate lipopolysaccharide-induced inflammation in ATDC5 eells by multiple mechanisms, Molecules, 2022, 27(17): 5619.
8. Zhongtang Li#; Guanxing Cai#; Fan Fang#; Wenchao Li; Minghua Fan; Jingjing Lian; Yinli Qiu; Xiangqing Xu; Xuehui Lv; Yiyan Li; Ruqiu Zheng; Yuxi Wang; Zhongjun Li; Guisen Zhang; Zhenming Liu*; Zhuo Huang*; Liangren Zhang*; Discovery of novel and potent N-methyl-D-aspartate receptor positive allosteric modulators with antidepressant-like activity in rodent models, Journal of Medicinal Chemistry, 2021, 64(9): 5551-5576.
